Milestone Highlights
Our achievements
Rare Pediatric Designation
In March 2023, our leading compound KIT-13 was granted Rare Pediatric Disease Designation from US FDA for treatment of Rett syndrome
Orphan Drug Designation
In March 2023, our leading compound KIT-13 was granted Orphan Drug Desigmation from US FDA for the treatment of Rett syndrome
A new company incorporated
In April 2023, NeuroCores is incorporated as a subsidiary of the Japanese prestige research institution, the Institute of Rheological Functions of Food
Publications
Research
Biological Functions of Plasmologen
Plasmalogens (Pls) are one kind of phospholipids enriched in the brain and other organs. These lipids were thought to be involved in the membrane bilayer formation and anti-oxidant function.
However, extensive studies reveal that Pls exhibits various beneficial biological activities including prevention of neuroinflammation, improvement of cognitive function, and inhibition of neuronal cell death.
Plasmalogens Rescue Neuronal Cell Death through an Activation of AKT and ERK Survival Signaling
Neuronal cells are susceptible to many stresses, which will cause the apoptosis and neurodegenerative diseases.
The precise molecular mechanism behind the neuronal protection against these apoptotic stimuli is necessary for drug discovery. In the present study, we have found that plasmalogens (Pls), which are glycerophospholipids containing vinyl ether linkage at sn-1 position, can protect the neuronal cell death upon serum deprivation.
Plasmalogens, the Vinyl Ether-Linked Glycerophospholipids, Enhance Learning and Memory by Regulating Brain-Derived Neurotrophic Factor
Plasmalogens (Pls), a kind of glycerophospholipids, have shown potent biological effects but their role in hippocampus-dependent memory remained mostly elusive. Here, we first report Pls can enhance endogenous expression of brain-derived neurotrophic factor (Bdnf) in the hippocampus and promotes neurogenesis associated with improvement of learning and memory in mice.
